Clustering of aberrations to specific chromosomes in human neoplasms
Identifieur interne : 000D18 ( Main/Exploration ); précédent : 000D17; suivant : 000D19Clustering of aberrations to specific chromosomes in human neoplasms
Auteurs : Felix Mitelman [Suède] ; Göran Levan [Suède]Source :
- Hereditas [ 0018-0661 ] ; 1981-09.
English descriptors
- Teeft :
- Aberration, Abnormality, Acta, Alimena, Berghe, Cancer genet, Causation, Chromosomal, Chromosomal aberrations, Chromosome, Chromosome aberrations, Chronic myelocytic leukemia, Chronic myeloid leukemia, Comm, Complex translocations, Cytogenet, Cytogenetic, Deletion, Different chromosome types, Engl, Fukuhara, Gahrton, Genet, Haematol, Hematol, Hereditas, Hossfeld, Human cancer, Human neoplasms, Kakati, Karyotype, Lable, Lancet, Lawler, Leukaemia, Leukemia, Levan, Lymphoma, Lymphoproliferative, Malignant, Marker chromosome, Marker chromosomes, Miielman, Milelman, Mitelman, Mitelman unpubl, Monosomy, Myeloblastic, Myelocytic, Myeloid, Myeloproliferative, Myeloproliferative disorders, Natl, Neoplasm, Nonrandom, Nowell, Oshimura, Pasquali, Pers, Polycythemia, Prigogina, Rowley, Sakurai, Sandberg, Scand, Tanzer, Translocation, Trisomy, Unpubl, Wiener, Zech.
Abstract
This survey of chromosomal aberrations in human neoplasms comprises 1,871 cases distributed on 15 groups of malignant disease, viz. 4 groups of myeloproliferative disorders with 1,328 cases, 5 groups of lymphoproliferative disorders with 369 cases and 6 groups of solid tumors with 174 cases. The material is presented in 17 tables, in which the variation of each chromosome is listed separately for each geographic region. In the discussion part a number of special problems are looked into. The difference in variation between the individual chromosomes was highly signifcant statistically. Within each tumor, all chromosomes which exceeded the average variation with more than 1 standard deviation were considered selectively involved. In all neoplasms taken together, the chromosomes selectively involved clustered to 15 of the 24 human chromosome types. Other topics taken up for discussion were the following: possible differences in chromosome variation between geographic regions; the specificity of certain marker chromosomes; the hypothesis of 2 essentially different kinds of chromosome aberration in cancer. The phenomena of genic amplification and recurrent translocation often found in cancer require the assumption of unorthodox cytogenetic mechanisms. One main conclusion of the paper is that the aberrations of the selectively involved chromosomes influence cancer development because of the genes they carry.
Url:
DOI: 10.1111/j.1601-5223.1981.tb01331.x
Affiliations:
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Lund</wicri:noRegion></affiliation></author><author><name sortKey="Levan, Goran" sort="Levan, Goran" uniqKey="Levan G" first="Göran" last="Levan">Göran Levan</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Genetics, University of Gothenburg</wicri:regionArea><wicri:noRegion>University of Gothenburg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Hereditas</title><title level="j" type="alt">HEREDITAS</title><idno type="ISSN">0018-0661</idno><idno type="eISSN">1601-5223</idno><imprint><biblScope unit="vol">95</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="79">79</biblScope><biblScope unit="page" to="139">139</biblScope><biblScope unit="page-count">61</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1981-09">1981-09</date></imprint><idno type="ISSN">0018-0661</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0018-0661</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aberration</term><term>Abnormality</term><term>Acta</term><term>Alimena</term><term>Berghe</term><term>Cancer genet</term><term>Causation</term><term>Chromosomal</term><term>Chromosomal aberrations</term><term>Chromosome</term><term>Chromosome aberrations</term><term>Chronic myelocytic leukemia</term><term>Chronic myeloid leukemia</term><term>Comm</term><term>Complex translocations</term><term>Cytogenet</term><term>Cytogenetic</term><term>Deletion</term><term>Different chromosome types</term><term>Engl</term><term>Fukuhara</term><term>Gahrton</term><term>Genet</term><term>Haematol</term><term>Hematol</term><term>Hereditas</term><term>Hossfeld</term><term>Human cancer</term><term>Human neoplasms</term><term>Kakati</term><term>Karyotype</term><term>Lable</term><term>Lancet</term><term>Lawler</term><term>Leukaemia</term><term>Leukemia</term><term>Levan</term><term>Lymphoma</term><term>Lymphoproliferative</term><term>Malignant</term><term>Marker chromosome</term><term>Marker chromosomes</term><term>Miielman</term><term>Milelman</term><term>Mitelman</term><term>Mitelman unpubl</term><term>Monosomy</term><term>Myeloblastic</term><term>Myelocytic</term><term>Myeloid</term><term>Myeloproliferative</term><term>Myeloproliferative disorders</term><term>Natl</term><term>Neoplasm</term><term>Nonrandom</term><term>Nowell</term><term>Oshimura</term><term>Pasquali</term><term>Pers</term><term>Polycythemia</term><term>Prigogina</term><term>Rowley</term><term>Sakurai</term><term>Sandberg</term><term>Scand</term><term>Tanzer</term><term>Translocation</term><term>Trisomy</term><term>Unpubl</term><term>Wiener</term><term>Zech</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This survey of chromosomal aberrations in human neoplasms comprises 1,871 cases distributed on 15 groups of malignant disease, viz. 4 groups of myeloproliferative disorders with 1,328 cases, 5 groups of lymphoproliferative disorders with 369 cases and 6 groups of solid tumors with 174 cases. The material is presented in 17 tables, in which the variation of each chromosome is listed separately for each geographic region. In the discussion part a number of special problems are looked into. The difference in variation between the individual chromosomes was highly signifcant statistically. Within each tumor, all chromosomes which exceeded the average variation with more than 1 standard deviation were considered selectively involved. In all neoplasms taken together, the chromosomes selectively involved clustered to 15 of the 24 human chromosome types. Other topics taken up for discussion were the following: possible differences in chromosome variation between geographic regions; the specificity of certain marker chromosomes; the hypothesis of 2 essentially different kinds of chromosome aberration in cancer. The phenomena of genic amplification and recurrent translocation often found in cancer require the assumption of unorthodox cytogenetic mechanisms. One main conclusion of the paper is that the aberrations of the selectively involved chromosomes influence cancer development because of the genes they carry.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Mitelman, Felix" sort="Mitelman, Felix" uniqKey="Mitelman F" first="Felix" last="Mitelman">Felix Mitelman</name></noRegion><name sortKey="Levan, Goran" sort="Levan, Goran" uniqKey="Levan G" first="Göran" last="Levan">Göran Levan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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